Clinical mechanism of quercetin affecting oxidative stress-related factors in ankylosing spondylitis
槲皮素影响强直性脊柱炎氧化应激相关因子的临床机制研究

摘要

目的 探讨天然黄酮类化合物槲皮素（Quercetin）对强直性脊柱炎（ankylosing spondylitis, AS）患者氧化应激相关因子的调控作用。方法 本研究纳入2024年7月-2025年6月于我院风湿免疫科就诊的100例确诊AS患者，按随机数字表法分为槲皮素干预组与常规治疗组各50例。两组均接受标准NSAIDs及基础治疗，干预组额外口服槲皮素500 mg/d，疗程12周。分别于治疗前后检测血清超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、丙二醛（MDA）水平，以及炎症指标C反应蛋白（CRP）和血沉（ESR），并评估BASDAI评分变化。结果 干预后两组均显示氧化应激水平改善，但槲皮素组SOD、GSH-Px水平均较对照组显著升高（P<0.05），MDA水平明显下降（P<0.01），CRP与ESR水平均明显降低（P<0.05）。BASDAI评分较基线显著下降，槲皮素组改善幅度优于对照组。结论 槲皮素可显著调节强直性脊柱炎患者体内氧化应激相关因子水平，发挥抗氧化和抗炎作用，有望成为AS治疗的辅助干预手段。

Abstract

Objective To investigate the regulatory effect of natural flavonoid compound Quercetin on oxidative stress-related factors in patients with ankylosing spondylitis (AS).
Methods This study included 100 diagnosed AS patients who visited the Rheumatology and Immunology Department of our hospital from July 2024 to July 2025. They were randomly divided into a quercetin intervention group and a conventional treatment group, with 50 patients in each group, using a random number table method. Both groups received standard NSAIDs and basic treatment, with the intervention group receiving an additional oral dose of 500 mg/d of quercetin for 12 weeks. Measure the levels of serum superoxide dismutase (SOD), glutathione peroxidase (GSH Px), malondialdehyde (MDA), as well as inflammatory markers C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) before and after treatment, and evaluate the changes in BASDAI score.
Results After intervention, both groups showed improvement in oxidative stress levels, but the levels of SOD and GSH Px in the quercetin group were significantly higher than those in the control group (P<0.05), the level of MDA was significantly decreased (P<0.01), and the levels of CRP and ESR were significantly decreased (P<0.05). The BASDAI score significantly decreased compared to baseline, and the improvement in the quercetin group was better than that in the control group.
Conclusion   Quercetin can significantly regulate the levels of oxidative stress-related factors in patients with ankylosing spondylitis, exert antioxidant and anti-inflammatory effects, and is expected to become an auxiliary intervention for AS treatment.