摘要
急性淋巴细胞白血病(ALL)是一种起源于淋巴细胞的B系或T系细胞在骨髓内异常增生的恶性肿瘤性疾病。目前针对ALL的主要治疗手段是化疗,然而,应用化疗药物不仅能够杀伤白血病细胞[1],也会对口腔黏膜等增殖旺盛的正常组织造成损伤,致使患者出现口腔黏膜炎[2]。口腔黏膜炎不仅会影响患者的进食及营养摄入、语言功能,还会降低患者的生活质量,甚至还可能引发感染,从而导致增加医疗费用及延长住院时间,并且对化疗的顺利进行也有着重大影响。因此,ALL患者化疗后出现口腔黏膜炎等的并发症相关研究进展得到全面深入的了解,我们能够提升患者的治疗效果、提高生活质量,临床应用价值显著。
关键词: 急性淋巴细胞白血病;化疗;口腔粘膜炎;护理举措
Abstract
Acute lymphoblastic leukemia (ALL) is a malignant tumor disease characterized by the abnormal proliferation of B-cell or T-cell lineage lymphocytes in the bone marrow. Currently, the primary treatment for ALL is chemotherapy. However, while chemotherapy drugs can kill leukemic cells [1], they also damage normal tissues with high proliferative activity, such as oral mucosa, leading to oral mucositis [2]. Oral mucositis not only affects patients 'eating and nutrient intake, speech function, but also reduces their quality of life. It can even lead to infections, increasing medical costs and hospital stays, and significantly impacting the smooth administration of chemotherapy. Therefore, comprehensive and in-depth research on complications such as oral mucositis after chemotherapy in ALL patients is essential. This can enhance treatment outcomes and improve patients' quality of life, demonstrating significant clinical value.
Key words: Acute lymphoblastic leukemia; Chemotherapy; Stomatitis; Nursing measures
参考文献 References
[1] 刘清池.当今急性白血病治疗的三步曲[C]//中华中医药学会.中华中医药学会第二届岐黄论坛——血液病中医药防治分论坛论文集.河北医科大学附属石家庄平安医院血液科;,2014:219-220.
[2] 黄晓莉,叶津津,唐月莲.Omega-3脂肪酸在预防乳腺癌化疗患者口腔黏膜炎中的效果[J].中国现代医生,2021, 59(04):26-29.
[3] 喻雅婷,周新,熊成敏,等.9种口腔护理液对癌症患者口腔黏膜炎预防效果的网状Meta分析[J].中国护理管理,2019,19(03):350-358.
[4] 叶知锋,黄挺,胡科科,等.自拟口愈灵方治疗化疗或靶向药物相关口腔黏膜炎的临床观察[J].中国中医药科技,2024,31(01):55-58.
[5] 张越.放化疗口腔黏膜炎的药物治疗策略[J].智慧健康,2022,8(28):41-44.
[6] 刘纯子,张燕,粱慧敏,等.Cox-IMCHB在急性淋巴细胞白血病学龄前儿童口腔黏膜炎干预中的应用研究[J].天津医科大学学报,2024,30(06):548-553.
[7] 彭美君,张祥忠,陆英,等.甲酰四氢叶酸钙溶液强化漱口减轻造血干细胞移植患者口腔黏膜炎程度[J].器官移植,2012,3(05):271-274.
[8] 裴志东,武阳,任铁军.氨磷汀对合并肝炎的恶性肿瘤化疗患者肝脏保护作用临床观察[J].陕西医学杂志,2010, 39(11):1521-1522.
[9] Hernandez G F A D C C A .Prevention of Oral Mucositis in Paediatric Patients with Acute Lymphoblastic Leukemia undergoing Chemotherapy: A randomized controlled, cross-over trial using 0.12% Chlorhexidine Gluconate and 1% Povidone Iodine Mouthwash[J].Journal of Palliative Care & Medicine,2020,10(4):1-6.
[10] Aisiyah N W ,Ardha P ,Rendi P , et al.Efficacy Oral Glutamine to Prevent Oral Mucositis and Reduce Hospital Costs During Chemotherapy in Children with Acute Lymphoblastic Leukemia.[J].Asian Pacific journal of cancer prevention : APJCP,2020,21(7):2117-2121.
[11] H. C ,M. S ,E. F .Effects of probiotics on clinical appearance of oral mucositis in children with leukemia during chemotherapy[J].International Journal of Dentistry and Oral Science,2020,7(11):1032-1036.
[12] Eraslan D ,Akyol A .CN107 The effect of Orem-based oral self-care protocol on high-dose chemotherapy-related oral mucositis and self-care agency in patients for hematologic malignancies: A randomized controlled study[J].Annals of Oncology,2024,35(S2):S1201-S1201.
[13] Khalil M ,Hamadah O ,Saifo M .Photobiomodulation preconditioning for oral mucositis prevention and quality of life improvement in chemotherapy patients: a randomized clinical trial[J].BMC Oral Health,2025,25(1):190-190.