Clinical analysis of low molecular weight heparin in the treatment of recurrent abortion after pregnancy obtained by human assisted reproductive technology
低分子肝素治疗人类辅助生殖技术获得妊娠后复发性流产的临床分析

摘要

目的 分析低分子肝素治疗人类辅助生殖技术获得妊娠后复发性流产的临床效果。方法 选择在我院于2023年1月-2024年1月内接受人类辅助生殖技术治疗后获得妊娠并发生复发性流产的100例患者作为研究对象，将其按随机分组方法分为对照组（50例，采取常规保胎治疗）和观察组（50例，在常规保胎治疗基础上加用低分子肝素治疗），对两组患者的妊娠结局、凝血功能指标、不良反应发生率及妊娠相关激素水平进行对比与评估。结果 观察组患者的D-二聚体、纤维蛋白原水平均低于对照组（P＜0.05）。观察组患者的不良反应发生率低于对照组（P＜0.05）。观察组患者的孕酮、人绒毛膜促性腺激素、雌二醇水平均高于对照组（P＜0.05）。观察组患者的流产率低于对照组（P＜0.05），早产率低于对照组（P＞0.05）。结论 在对接受人类辅助生殖技术治疗后获得妊娠并发生复发性流产的患者实施低分子肝素治疗取得明显效果，显著改善患者的激素水平和凝血功能指标，降低不良反应发生率及流产率，有较高的应用价值。

Abstract

Objective To analyze the clinical effect of low molecular weight heparin in the treatment of recurrent abortion after pregnancy obtained by human assisted reproductive technology.
Methods A total of 100 patients with recurrent abortion after receiving human assisted reproductive technology treatment in our hospital from January 2023 to January 2024 were selected as the study objects, and they were divided into control group (50 cases, routine fetal preservation treatment) and observation group (50 cases, clinical treatment) according to random grouping method. The pregnancy outcome, coagulation function index, incidence of adverse reactions and pregnancy-related hormone levels of the two groups were compared and evaluated.
Results The average levels of D-dimer and fibrinogen in observation group were lower than those in control group (P < 0.05). The incidence of adverse reactions in observation group was lower than that in control group (P < 0.05). The levels of progesterone, human chorionic gonadotropin and estradiol in observation group were higher than those in control group (P < 0.05). The abortion rate in observation group was lower than that in control group (P < 0.05), and the premature birth rate was lower than that in control group (P > 0.05).
Conclusion   The treatment of low molecular weight heparin in the patients with pregnancy and recurrent abortion after receiving assisted reproductive technology has achieved obvious effect, significantly improving the hormone level and coagulation function index of patients, and reducing the incidence of adverse reactions and abortion rate, which has high application value.