Study on improvement of quality of life of silicosis patients with Jinbei oral liquid
金贝口服液对矽肺患者生活质量改善的研究

摘要

目的 本研究旨在观察金贝口服液治疗矽肺患者的疗效，尤其关注其对呼吸功能的改善及生活质量的提升，旨在为矽肺的抗纤维化中药治疗提供科学依据。方法 本研究共选取40名矽肺患者（壹期15例、贰期10例、叁期15例），并将其随机分为治疗组和对照组，两组均接受常规抗炎、止咳、平喘治疗。治疗组在此基础上额外使用金贝口服液20ml，每日三次，持续用药3个月。主要观察指标包括肺功能指标（FVC、FEV1、FEV1/FVC、PEF）、六分钟步行试验、MRC呼吸困难分级、CAT评分、CET咳嗽程度评分及生活质量评分，以及咳嗽、咳痰症状的变化。治疗6个月后，进一步观察上述指标及胸部CT和胸片的变化。结果 治疗组患者在使用金贝口服液后，肺功能指标、六分钟步行试验成绩显著改善，MRC呼吸困难分级、CAT评分及CET咳嗽程度评分均有显著下降，生活质量评分显著提高。与对照组相比，治疗组在咳嗽、咳痰症状减轻、肺功能改善及生活质量提升方面均有显著差异（P<0.05）。结论 金贝口服液能显著改善矽肺患者的呼吸功能和生活质量，减轻症状，提升患者的整体健康状态。该研究结果表明，金贝口服液作为一种抗纤维化的中药，对矽肺患者具有明显的治疗效果，可作为矽肺综合治疗策略的重要组成部分。此项研究为矽肺的中医药治疗提供了新的思路和证据，支持了金贝口服液在矽肺治疗中的应用价值。

Abstract

Objective This study was to observe the curative effect of Jinbei oral liquid in the treatment of silicosis patients, especially its improvement of respiratory function and quality of life, in order to provide scientific basis for the treatment of silicosis with traditional Chinese medicine against fibrosis.
Methods A total of 40 silicosis patients (15 cases in stage 1, 10 cases in stage 2 and 15 cases in stage 3) were selected and randomly divided into treatment group and control group. Both groups received conventional anti-inflammation, antitussive and antiasthmatic treatment. The treatment group was given an additional 20ml of Jinbei oral liquid three times a day for 3 months. The main outcome measures included pulmonary function indicators (FVC, FEV1, FEV1/FVC, PEF), six-minute walking test, MRC dyspnea grade, CAT score, CET cough severity score and quality of life score, and changes in cough and expectoration symptoms. After 6 months of treatment, the above indexes and the changes of chest CT and chest radiograph were further observed.
Results In the treatment group, after using Jinbe oral liquid, the pulmonary function index and the score of 6-minute walking test were significantly improved, the MRC dyspnea grade, CAT score and CET cough degree score were significantly decreased, and the quality of life score was significantly improved. Compared with the control group, the treatment group had significant differences in the alleviation of cough and expectoration symptoms, improvement of lung function and improvement of quality of life (P<0.05).
Conclusion   Jinbei oral liquid can significantly improve the respiratory function and quality of life of silicosis patients, alleviate symptoms and improve the overall health of the patients. The results show that Jinbei oral liquid, as an anti-fibrosis Chinese medicine, has obvious therapeutic effect on silicosis patients, and can be used as an important part of the comprehensive treatment strategy for silicosis. This study provides a new idea and evidence for the treatment of silicosis with traditional Chinese medicine, and supports the application value of Jinbei oral liquid in the treatment of silicosis.