Analysis of related factors of oral mucositis in patients with head and neck radiotherapy
头颈部放疗患者致口腔粘膜炎的相关因素分析

摘要

目的 分析头颈部放疗患者引起口腔粘膜炎（OM）的相关危险因素。方法 回顾性分析2021年1月至2022年3月本院开展放疗的102例头颈部恶性肿瘤患者临床资料，统计OM发生情况，将发生OM患者作为OM组，将未发生OM患者作为无OM组。通过单因素及多因素Logistic回归分析头颈部放疗引起OM的危险因素。结果 本组102例患者共有91例发生OM，发生率达到89.22%。单因素分析可知，两组间年龄、吸烟史、同步放化疗存在统计学差异（P＜0.05）；而两组间性别、饮酒史、身高、体重不存在统计学差异（P＞0.05）。多因素分析可知，高龄、合并吸烟史、同步放化疗是头颈部放疗引起OM的危险因素（P＜0.05）。结论 头颈部放疗患者发生OM的风险较高，包括吸烟史、高龄、同步放化疗均是常见影响因素。

Abstract

Objective To analyze the risk factors of oral mucositis (OM) in patients with head and neck radiotherapy.
Methods Clinical data of 102 patients with malignant tumors of head and neck undergoing radiotherapy in our hospital from January 2021 to March 2022 were retrospectively analyzed, and the incidence of OM was statistically analyzed. Patients with OM were classified as the OM group and those without OM were classified as the group without OM. The risk factors of OM induced by head and neck radiotherapy were analyzed by univariate and multivariate logistic regression.
Results OM occurred in 91 of 102 patients, with an incidence of 89.22%. Univariate analysis showed that there were significant differences in age, smoking history and concurrent chemoradiotherapy between the two groups (P < 0.05). There were no significant differences in gender, drinking history, height and weight between the two groups (P > 0.05). Multivariate analysis showed that old age, combined smoking history and concurrent chemoradiotherapy were risk factors for OM induced by head and neck radiotherapy (P < 0.05).
Conclusion   Patients with head and neck radiotherapy have a higher risk of OM, including smoking history, old age, concurrent chemoradiotherapy are common influencing factors.