Clinical observation of bipolar disorder and study on the distribution of related etiology and TCM syndrome types
双相情感障碍的临床观察及相关病因、中医证型分布规律的研究

摘要

目的 本次研究主要探究双相情感障碍患者的中医证型以及病因。方法 研究进行时间为2022年1月-2023年1月，研究对象是我院接收的400例双相情感障碍患者，研究运用中医四诊合诊来对患者进行诊断，对患者的中医辨证与症候指标进行研究，并且评价不同证型双相抑郁患者的抑郁症状、双相躁狂患者的躁狂发作。结果 双相抑郁和双相躁狂的中医证型对比，无明显差异，p＞0.05；双相抑郁与双相躁狂患者占比最高的证型是痰热内扰证。双相躁狂患者的痰热内扰证YMRS评分要比其他证型高，p＜0.05；双相抑郁患者不同证型的SDS评分无明显差异，p＞0.05。结论 双相情感障碍患者的主要中医证型是痰热内扰证，不同证型的双相躁狂患者与双相抑郁患者均出现不良症状，临床需重视双相情感障碍患者的治疗。

Abstract

Objective This study is mainly to explore the TCM syndrome types and etiology of patients with bipolar disorder.
Methods The study was conducted from January 2022 to January 2023. The subjects of the study were 400 patients with bipolar disorder received by our hospital. The study used the four diagnostic methods of traditional Chinese medicine to diagnose the patients, studied the syndrome differentiation and symptom indicators of the patients, and evaluated the depressive symptoms of patients with bipolar depression of different syndrome types and the manic episode of patients with bipolar mania.
Results there was no significant difference between bipolar depression and bipolar mania (p>0.05); The highest proportion of patients with bipolar depression and bipolar mania is phlegm-heat syndrome. The YMRS score of phlegm-heat disturbance syndrome in bipolar manic patients was higher than that of other syndrome types (p<0.05); There was no significant difference in SDS scores of different syndrome types in patients with bipolar depression (p>0.05).
Conclusion   The main TCM syndrome type of patients with bipolar affective disorder is phlegm-heat internal disturbance syndrome. Bipolar manic patients and bipolar depression patients with different syndrome types have adverse symptoms. Clinical attention should be paid to the treatment of patients with bipolar affective disorder.